Labex was implemented in the United States in 1998 to consolidate partnerships with scientific teams of recognized competence, implement common interest strategic research and identify trends with potential common benefits to Brazilian and American agribusiness. The main partner and signatory of the international agreement with Embrapa is the Agricultural Research Service - ARS of the United State Department of Agriculture - USDA. To date, priority in research has included the areas of nanotechnology, climate change, precision agriculture, integrated pest management, plant and animal genetic resources, animal health, agro-forestry and, more recently, the discovery and use of substances from biodiversity, advanced biology applied to drought tolerance and control of the Citrus Huanglongbing. Expansion in international scientific cooperation between Brazil and other countries continued with the creation of Labex Europe in 2002, initially in Montpellier, France, through an agreement with Agropolis, an association congregating several agricultural innovation institutions. Subsequent European cooperation has expanded to Netherlands, United Kingdom and Germany. Cooperation with Europe encompasses areas of food technology, environmental science, biotechnology, and genomics of plant-pathogen interactions. Labex Korea was created in 2009 - the first Labex experience in Asia in the field of genetic resources. Labex Asia is presently expanding to China in 2012 and Japan in 2013. Such an innovative initiative created opportunities for international cooperation by enabling strategic monitoring of scientific and technological advancements, as well as the implementation of research based on common interests in various subjects with a number of international scientific organizations. Embrapa networks and research teams are expanding through actions of cooperation and capacity building that emphasize scientific, technological and managerial exchanges. Partnerships with groups of excellence in the world are being consolidated. Researchers are gaining access to new knowledge and are sharing experiences in technological innovation processes. Collaborative projects are delivering products and processes such as nanocomposites from renewable resource, methods to prevent contaminating food of animal origin, new methodologies to assess carbon in soils, definitions of molecular markers for soybean rust disease, rapid diagnostic methods in animal health, systematic research with mushrooms, exchanges in genetic resources, among many others. A new cooperation in natural resources will further expand the range of opportunities in research by defining new methodologies, concepts and processes to meet present and future challenges for an effective sustainable agriculture.